Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.

@article{Mak2009NaturalHO,
  title={Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.},
  author={George J. Mak and Mark Thomas Ledwidge and Christopher J E Watson and Dermot M Phelan and Ian R Dawkins and Niamh F Murphy and Anil K Patle and John A. Baugh and Kenneth M. McDonald},
  journal={Journal of the American College of Cardiology},
  year={2009},
  volume={54 18},
  pages={1674-82}
}
OBJECTIVES This study was designed to evaluate the impact of eplerenone on collagen turnover in preserved systolic function heart failure (HFPSF). BACKGROUND Despite growing interest in abnormal collagen metabolism as a feature of HFPSF with diastolic dysfunction, the natural history of markers of collagen turnover and the impact of selective aldosterone antagonism on this natural history remains unknown. METHODS We evaluated 44 patients with HFPSF, randomly assigned to control (n = 20) or… CONTINUE READING
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