Natural history of early primary biliary cirrhosis

  title={Natural history of early primary biliary cirrhosis},
  author={Jane V Metcalf and H C Mitchison and Jeremy Palmer and David E. J. Jones and Oliver F. W. James},
  journal={The Lancet},
BACKGROUND In 1986, we reported a group of 29 patients who were positive in serum for antimitochondrial antibody (AMA), the disease-specific marker for primary biliary cirrhosis (PBC), but who had normal liver function test results and no symptoms of liver disease. However, liver histology was diagnostic or compatible with PBC in 24 patients and normal in only two. The aims of this 10-year follow-up study were to establish whether patients with AMA have very early PBC, to assess the outlook for… CONTINUE READING


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