Natural history of dilated cardiomyopathy due to lamin A/C gene mutations.

  title={Natural history of dilated cardiomyopathy due to lamin A/C gene mutations.},
  author={Matthew R. G. Taylor and Pamela R. Fain and Gianfranco Sinagra and Misi L Robinson and Alastair D. Robertson and Elisa Carniel and Andrea di Lenarda and Teresa J Bohlmeyer and Debra A Ferguson and Gary L. Brodsky and Mark M. Boucek and Jean Lascor and Andrew C Moss and Wai Lun P Li and Gary L. Stetler and Francesco Muntoni and Michael R. Bristow and Luisa Mestroni},
  journal={Journal of the American College of Cardiology},
  volume={41 5},
OBJECTIVES We examined the prevalence, genotype-phenotype correlation, and natural history of lamin A/C gene (LMNA) mutations in subjects with dilated cardiomyopathy (DCM). BACKGROUND Mutations in LMNA have been found in patients with DCM with familial conduction defects and muscular dystrophy, but the clinical spectrum, prognosis, and clinical relevance of laminopathies in DCM are unknown. BACKGROUND A cohort of 49 nuclear families, 40 with familial DCM and 9 with sporadic DCM (269… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 126 extracted citations

Familiäre dilatative Kardiomyopathie

View 4 Excerpts
Highly Influenced

Lamin A/C mutations in dilated cardiomyopathy.

Cardiology journal • 2014
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 41 references

Nuclear lamins: their structure, assembly, and interactions.

Journal of structural biology • 1998
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…