Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia.

@article{Shimakawa2016NaturalHO,
  title={Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia.},
  author={Yusuke Shimakawa and Maud Lemoine and Harr Freeya Njai and Christian Bottomley and Gibril Ndow and R Goldin and Abdoulie Jatta and Adam Jeng-Barry and Rita Wegmuller and S E Moore and Ignatius Baldeh and Makie Taal and Umberto D'Alessandro and Hilton C. Whittle and Ramou Njie and Mark Thursz and Maimuna Mendy},
  journal={Gut},
  year={2016},
  volume={65 12},
  pages={2007-2016}
}
BACKGROUND The natural history of chronic HBV infection in sub-Saharan Africa is unknown. Data are required to inform WHO guidelines that are currently based on studies in Europe and Asia. METHODS Between 1974 and 2008, serosurveys were repeated in two Gambian villages, and an open cohort of treatment-naive chronic HBV carriers was recruited. Participants were followed to estimate the rates of hepatitis B e (HBeAg) and surface antigen (HBsAg) clearance and incidence of hepatocellular… CONTINUE READING