Natural history of central nervous system acute leukemia in adults.

  title={Natural history of central nervous system acute leukemia in adults.},
  author={David J. Stewart and Michael J Keating and Kenneth B. McCredie and Terry L. Smith and E L Youness and Samuel G. Murphy and Gerald Paul Bodey and Emil J. Freireich},
  volume={47 1},
Central nervous system (CNS) involvement occurred in 45 of 222 (20.3%) leukemic adults achieving bone marrow (BM) complete remission (CR), including 12 of 23 (52%) acute undifferentiated leukemia (AUL), 12 of 32 (39%) lymphoma leukemia, 5 of 26 (19%) acute lymphoblastic leukemia, and 16 of 142 (11%) acute myelogenous leukemia. Risk factors for CNS disease were lactic dehydrogenase (LDH) greater than or equal to 25,000/mm3. AUL morphology, age less than 20 years, and extramedullary involvement… CONTINUE READING


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