Natural history of celiac disease autoimmunity in a USA cohort followed since 1974.

  title={Natural history of celiac disease autoimmunity in a USA cohort followed since 1974.},
  author={Carlo Catassi and Debby Kryszak and Bushra Bhatti and Craig Sturgeon and Kathy J. Helzlsouer and Sandra L. Clipp and Daniel Gelfond and Elaine L Leonard Puppa and Anthony D Sferruzza and Alessio Fasano},
  journal={Annals of medicine},
  volume={42 7},
BACKGROUND The natural history and the possible changes of celiac disease (CD) prevalence over time are still unclear. OBJECTIVES 1) To establish whether loss of tolerance to gluten may occur at any age; 2) to investigate possible changes of CD prevalence over time; and 3) to investigate CD-related co-morbidities. METHODS We analyzed 3,511 subjects with matched samples from 1974 (CLUE I) and 1989 (CLUE II). To avoid a selection bias regarding survival, we also screened 840 CLUE I… CONTINUE READING
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