Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population.

@article{Kimpimki2002NaturalHO,
  title={Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population.},
  author={Teija Kimpim{\"a}ki and Petri Kulmala and Kaisa Savola and Antti Kupila and Sari Hannele Korhonen and Tuula T. Simell and Jorma Ilonen and Olli Simell and Mikael Knip},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 10},
  pages={4572-9}
}
The aim of this study was to evaluate the frequency and predictive value of diabetes-associated autoantibodies, such as islet cell antibodies (ICA) and autoantibodies to insulin (IAA), GAD65 (GADA), and the IA-2 molecule (IA-2A) in genetically susceptible children from the general population during the first 2 yr of life. Of 12,170 newborn infants, 1,005 with increased genetic risk of type 1 diabetes (high risk, human leukocyte antigen DQB1*02/*0302; moderate risk, DQB1*0302/x, where x = other… CONTINUE READING
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