Natural history and prognostic factors for chronic hepatitis type B.

@article{Fattovich1991NaturalHA,
  title={Natural history and prognostic factors for chronic hepatitis type B.},
  author={Giovanna Fattovich and Loris Brollo and Giuliano Giustina and Franco Noventa and Patrizia Pontisso and Alfredo Alberti and Giuseppe Realdi and Arturo Ruol},
  journal={Gut},
  year={1991},
  volume={32 3},
  pages={294-8}
}
One hundred and five hepatitis B surface antigen (HBsAg) positive patients presenting with chronic persistent hepatitis (n = 46) or chronic active hepatitis without cirrhosis (n = 59) were followed longitudinally for one to 16 years (mean 5.5 years) and underwent follow up biopsy. During a mean histological follow up of 3.7 years, active cirrhosis developed in 21 (20%) patients one to 13 years after entry to the study with a calculated annual incidence of 5.9%. The probability of evolution to… CONTINUE READING