Natural history and pathogenesis of human immunodeficiency virus infection.

@article{Burger2003NaturalHA,
  title={Natural history and pathogenesis of human immunodeficiency virus infection.},
  author={Susanne Burger and Michael A. Poles},
  journal={Seminars in liver disease},
  year={2003},
  volume={23 2},
  pages={
          115-24
        }
}
In this article, we discuss how human immunodeficiency virus (HIV) infection of activated CD4+ cells, expressing the chemokine receptors CCR5 or CXCR4, results in severe immunosuppression while evading the immune response. We describe how infection through mucosal surfaces or via the parenteral route results in rapid spread of the virus throughout the body prior to a vigorous CD8+ cytolytic T cell response, resulting in establishment of a viral set point. Data is examined that suggests the half… CONTINUE READING
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