Natural history, risk factors, and impact of subclinical rejection in kidney transplantation.

@article{Nankivell2004NaturalHR,
  title={Natural history, risk factors, and impact of subclinical rejection in kidney transplantation.},
  author={Brian John Nankivell and Richard J Borrows and Caroline L-S Fung and Philip J. O'connell and Richard D. M. Allen and Jeremy Robert Chapman},
  journal={Transplantation},
  year={2004},
  volume={78 2},
  pages={
          242-9
        }
}
BACKGROUND Subclinical rejection (SCR) is defined as histologically proven acute rejection in the absence of immediate functional deterioration. METHODS We evaluated the impact of SCR in 961 prospective protocol kidney biopsies from diabetic recipients of a kidney-pancreas transplant (n=119) and one kidney transplant alone taken regularly up to 10 years after transplantation. RESULTS SCR was present in 60.8%, 45.7%, 25.8%, and 17.7% of biopsies at 1, 3, 12, and greater than 12 months after… CONTINUE READING

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