Natural genetic exchanges between vaccine and wild poliovirus strains in humans.

@article{Guillot2000NaturalGE,
  title={Natural genetic exchanges between vaccine and wild poliovirus strains in humans.},
  author={Sophie Guillot and Val{\'e}rie Caro and N S Cuervo and Ekaterina A. Korotkova and Mariana Combiescu and Ana Persu and Andrei Aubert-Combiescu and Françis Delpeyroux and Radu Crainic},
  journal={Journal of virology},
  year={2000},
  volume={74 18},
  pages={8434-43}
}
In a previous study of poliovirus vaccine-derived strains isolated from patients with vaccine-associated paralytic poliomyelitis (VAPP) (9, 11), we reported that a high proportion (over 50%) of viruses had a recombinant genome. Most were intertypic vaccine/vaccine recombinants. However, some had restriction fragment length polymorphism (RFLP) profiles different from those of poliovirus vaccine strains. We demonstrate here that five such recombinants, of 88 VAPP strains examined, carried… CONTINUE READING
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