Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells

@article{Herberman1975NaturalCR,
  title={Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells},
  author={Ronald B. Herberman and Myrthel E. Nunn and Howard T. Holden and David H. Lavrin},
  journal={International Journal of Cancer},
  year={1975},
  volume={16}
}
Studies were performed to characterize the effector cells responsible for natural cytotoxicity of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since spleen cells from normal nude mice were found to be highly cytotoxic, they were used for most of these experiments. Only a small proportion of the reactivity was affected by treatment with anti‐θ serum plus complement. Macrophages did not appear to be responsible for the reactivity, since treatment with carbonyl… 
Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity
TLDR
Lymphoid cells from many normal mice of a variety of inbred strains were found to have reactivity, in a 51Cr release cytotoxicity assay, against several syngeneic and allogeneic tumors, apparently associated with expression of murine endogenous type‐C viruses.
Augmentation of natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic target cells
TLDR
The results indicate that the levels of natural cell‐mediated cytotoxicity in conventional and athymic BALB/c mice can be consistently and rapidly boosted by inoculation with tumor cells or viruses.
Natural cytotoxicity of haemopoietic cell populations against murine lymphoid tumours.
TLDR
It was found that cell suspensions from nude mice were always significantly more active than those from normal mice, and that the most active effector population was a polymorph-enriched peritoneal-exudate cell suspension.
Mechanisms of cellular cytotoxicity mediated by effector cells from rats with spontaneous tumors
TLDR
It is proved that in a long‐term assay, the presence of B cells is indeed mainly responsible for increased TB cytotoxicity, since: (1) After depletion of surface immunoglobulin positive cells (s‐Ig+), TB cytOToxicity no longer exceeds cytot toxicity of effector cells from untreated rats.
Natural cytotoxicity to human leukemia mediated by mouse non‐t cells
TLDR
It is shown that mouse NK cells also function in a xenogeneic system, and unlabelled mouse T lymphoma YAC‐1 cells were efficient competitors for lysis of human T leukemia lines.
Biology of Natural Killer Cells
In vivo natural reactivity of mice against tumor cells
TLDR
The data indicate that rapid in vivo clearance of radiolabelled NK‐sensitive tumor cell lines is appreciably influenced by levels of NK reactivity, but that other factors are probably also involved.
Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems
TLDR
The present results further distinguish the NK cell from cytotoxic T lymphocytes or from antibody- dependent killer cells.
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References

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Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity
TLDR
Lymphoid cells from many normal mice of a variety of inbred strains were found to have reactivity, in a 51Cr release cytotoxicity assay, against several syngeneic and allogeneic tumors, apparently associated with expression of murine endogenous type‐C viruses.
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TLDR
The data strongly suggest that the inihibitor cells of lymphoma cell DNA synthesis are macrophages and that they belong to the same group of cells as the suppressor cells of PHA-induced lymphocyte proliferation.
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TLDR
The lytic activity of the spleen cell suspensions towards the mastocytoma cells was completely abolished by removal of θ-antigen bearing cells, and the lysis of DBA/2 mastocyToma cells by immune C57B1 lymphocytes was unaffected by treatment with any of the anti-immunoglobulin reagents.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Neoplastic target cell death was not characteristically mediated by such sera alone or by normal lymphoid cells in the presence of serum from animals bearing some other tumor, but appeared to be a specific, synergistically produced cytotoxicity.
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