Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.

@article{Yang2008NaturalCW,
  title={Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.},
  author={Huanjie Yang and Kristin R Landis-Piwowar and Dongfeng Chen and Vesna Milacic and Q Ping Dou},
  journal={Current protein & peptide science},
  year={2008},
  volume={9 3},
  pages={
          227-39
        }
}
The proteasome is a multicatalytic protease complex that degrades most endogenous proteins including misfolded or damaged proteins to ensure normal cellular function. The ubiquitin-proteasome degradation pathway plays an essential role in multiple cellular processes, including cell cycle progression, proliferation, apoptosis and angiogenesis. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that a proteasome inhibitor could be… CONTINUE READING