Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'.

  title={Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'.},
  author={Stratis Avrameas},
  journal={Immunology today},
  volume={12 5},
The immune system of normal unimmunized animals is characterized by the presence of B cells synthesizing and secreting mainly polyreactive, but also monoreactive, IgM and IgG natural antibodies that can react with a variety of self constituents. These antibodies, like the autoantibodies appearing in several immunopathological states, use the same genetic elements as the antibodies directed against environmental antigens, and seem to be encoded by unmutated germ-line genes. Accumulating evidence… CONTINUE READING
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