Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3.

@article{Chen1991NaturalAA,
  title={Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3.},
  author={Cui Cui Chen and Mary P. Stenzel-Poore and Marvin B. Rittenberg},
  journal={Journal of immunology},
  year={1991},
  volume={147 7},
  pages={2359-67}
}
We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%. These sets were found among 49 neonatal and adult natural mAb that were compared with 35 Ag-induced monoclonals produced during the memory response to phosphocholine (PC)-keyhole limpet hemocyanin. Both groups of monoclonals had been selected on the basis of a restricted fine specificity pattern… CONTINUE READING

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