Natural antioxidants and hypertension: promise and challenges.

  title={Natural antioxidants and hypertension: promise and challenges.},
  author={Tinoy J Kizhakekuttu and Michael E Widlansky},
  journal={Cardiovascular therapeutics},
  volume={28 4},
Hypertension reigns as a leading cause of cardiovascular morbidity and mortality worldwide. Excessive reactive oxygen species (ROS) have emerged as a central common pathway by which disparate influences may induce and exacerbate hypertension. Potential sources of excessive ROS in hypertension include nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, mitochondria, xanthine oxidase, endothelium-derived NO synthase, cyclooxygenase 1 and 2, cytochrome P450 epoxygenase, and transition… CONTINUE READING
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