Natural and synthetic non-peptide antigens recognized by human γδ T cells

@article{Tanaka1995NaturalAS,
  title={Natural and synthetic non-peptide antigens recognized by human γδ T cells},
  author={Yoshimasa Tanaka and Craig T. Morita and Yoko Tanaka and Edward Nieves and Michael B Brenner and Barry R. Bloom},
  journal={Nature},
  year={1995},
  volume={375},
  pages={155-158}
}
T LYMPHOCYTES express either αβ or γδ T-cell receptor heterodimers1,2. Most αβ T cells recognize antigenic peptides bound to major histocompatibility complex molecules but the antigen recognition and biological function of γδ T cells is unknown. A major human γδ T-cell subset expressing Vγ2 and Vδ2 germline genes, but having diverse junctional sequences, is found in human mycobacterial lesions3 and responds in vitro to antigens of bacteria and parasites4–8. In addition, certain haematopoietic… CONTINUE READING