Natural and synthetic betaines counter the effects of high NaCl and urea concentrations.

@article{Randall1996NaturalAS,
  title={Natural and synthetic betaines counter the effects of high NaCl and urea concentrations.},
  author={K. Randall and M. Lever and B. Peddie and S. Chambers},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1291 3},
  pages={
          189-94
        }
}
  • K. Randall, M. Lever, +1 author S. Chambers
  • Published 1996
  • Chemistry, Medicine
  • Biochimica et biophysica acta
    • Escherichia coli was used as a model system to evaluate a range of betaines for their ability to protect against salt and urea stresses. Betaine structure determined the salt and urea protective effects. Dimethylthetin conferred salt protection similar to glycine betaine, whereas dimethylsulfoniopropionate (DMSP) was less effective than either glycine betaine or dimethylthetin, but similar to propionobetaine (its nitrogen analogue). Hydrophobic alpha-substituents altered salt tolerance. Valine… CONTINUE READING
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    32 Citations
    Highly Influencial Citations
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    Background Citations
    13
    Methods Citations
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    Results Citations
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    32 Citations
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    References

    SHOWING 1-10 OF 19 REFERENCES
    Dimethylthetin can substitute for glycine betaine as an osmoprotectant molecule for Escherichia coli.
    • 118
    • PDF
    Competitive accumulation of betaines by Escherichia coli K-12 and derivative strains lacking betaine porters.
    • 31
    The osmoprotective properties of urine for bacteria: the protective effect of betaine and human urine against low pH and high concentrations of electrolytes, sugars, and urea.
    • 74
    The stabilization of proteins by osmolytes.
    • 830
    A Study of Modified Betaines as Cryoprotective Additives
    • 18
    Relationship between osmoprotection and the structure and intracellular accumulation of betaines by Escherichia coli.
    • 46
    • PDF
    Increased thermal stability of proteins in the presence of naturally occurring osmolytes.
    • 365
    Same-day batch measurement of glycine betaine, carnitine, and other betaines in biological material.
    • 56
    Living with water stress: evolution of osmolyte systems.
    • 3,355
    Renal medullary organic osmolytes.
    • 474