Natural and synthetic betaines counter the effects of high NaCl and urea concentrations.

@article{Randall1996NaturalAS,
  title={Natural and synthetic betaines counter the effects of high NaCl and urea concentrations.},
  author={K. Randall and M. Lever and B. Peddie and S. Chambers},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1291 3},
  pages={
          189-94
        }
}
  • K. Randall, M. Lever, +1 author S. Chambers
  • Published 1996
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • Escherichia coli was used as a model system to evaluate a range of betaines for their ability to protect against salt and urea stresses. Betaine structure determined the salt and urea protective effects. Dimethylthetin conferred salt protection similar to glycine betaine, whereas dimethylsulfoniopropionate (DMSP) was less effective than either glycine betaine or dimethylthetin, but similar to propionobetaine (its nitrogen analogue). Hydrophobic alpha-substituents altered salt tolerance. Valine… CONTINUE READING
    32 Citations
    Betaine analogues and related compounds for biomedical applications
    • 1
    • Highly Influenced
    Enzyme stabilization using synthetic compensatory solutes
    • 7
    Osmoprotective activity, urea protection, and accumulation of hydrophilic betaines in Escherichia coli and Staphylococcus aureus
    • 16
    Exclusion and retention of compensatory kosmotropes by HPLC columns.
    • M. Lever
    • Medicine, Chemistry
    • Biochimica et biophysica acta
    • 1998
    • 8
    Mechanical Insight into Resistance of Betaine to Urea-Induced Protein Denaturation.
    • 7
    Osmoprotective properties and accumulation of betaine analogues by Staphylococcus aureus.
    • 26
    • PDF

    References

    SHOWING 1-10 OF 19 REFERENCES
    The stabilization of proteins by osmolytes.
    • 830
    A Study of Modified Betaines as Cryoprotective Additives
    • 18
    Renal medullary organic osmolytes.
    • 474