Natural and synthetic G-quadruplex interactive berberine derivatives.

@article{Franceschin2006NaturalAS,
  title={Natural and synthetic G-quadruplex interactive berberine derivatives.},
  author={Marco Franceschin and Luigi Rossetti and A. D’Ambrosio and Stefano Schirripa and Armandodoriano Bianco and Giancarlo Ortaggi and M. De Santis Savino and Christoph M Schultes and Stephen Neidle},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2006},
  volume={16 6},
  pages={
          1707-11
        }
}
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184 Citations
Highly Influential Citations
5
Background Citations
44
Methods Citations
6

184 Citations

Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligands.

9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA.

Selective Interactions with Various G-Quadruplex DNA Forming Sequences by Berberine and Palmatine Analogues

In this article/review, the selective interactions of several berberine and palmatine derivatives with various DNA G-quadruplex structures are reported. These derivatives were constructed starting…

A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives.

ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives, which showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure.

Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G- quadruplex structures.

Xanthene and Xanthone Derivatives as G-Quadruplex Stabilizing Ligands

The dimeric compound and the three-side chain xanthone derivative have been shown to represent the best compounds emerging from the different series of ligands presented here, having also high selectivity for G-quadruplex structures with respect to duplex DNA.

Study of alkaloid berberine and its interaction with the human telomeric i-motif DNA structure.

Screening potential antitumor agents from natural plant extracts by G-quadruplex recognition and NMR methods.

This work addresses the address of a novel approach for fast screening of G-quadruplex ligands from natural plant extracts, a complicated mixtures system with multiform unknown chemical frames, with known structure.

Non-Flat Bisbenzylisoquinoline Alkaloid Fangchinoline As a Class of Potent G-Quadruplex Stabilizer with Anti-cancer Activity

Compounds selectively binding and stabilizing G-quadruplex structures could inhibit the telomerase or down- regulate the oncogenes and may act as anti-cancer drugs. An alkaloid with non-flat…
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