Natural and artificial enzymes against cocaine. I. Monoclonal antibody 15A10 and the reinforcing effects of cocaine in rats.

@article{Baird2000NaturalAA,
  title={Natural and artificial enzymes against cocaine. I. Monoclonal antibody 15A10 and the reinforcing effects of cocaine in rats.},
  author={T J Baird and Shirley X Deng and Donald W. Landry and Gail D. Winger and J. H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 3},
  pages={1127-34}
}
Recent reports have indicated the potential usefulness of anticocaine catalytic monoclonal antibodies in reducing cocaine's toxic and reinforcing effects by altering its pharmacokinetics to favor increased metabolism to the systemically inert products ecgonine methylester and benzoic acid. The present study was designed to further these findings by evaluating the hypothesis that administration of the anticocaine catalytic monoclonal antibody mAb 15A10 would dose and time dependently reduce… CONTINUE READING

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