Natural and Synthetic TLR 7 Ligands Inhibit CpG-Aand CpG-C-Oligodeoxynucleotide-Induced IFN-Production 1

Plasmacytoid dendritic cells (pDCs) are unique with respect to their capacity to produce unsurpassed amounts of IFNand coexpress TLR7 and TLR9, mediating IFNproduction. Although TLRs are critical receptors of innate immunity, little is known about the immunological effects of TLR7/TLR9 costimulation. We have analyzed the effects of TLR7/TLR9 costimulation… CONTINUE READING