Natural and Enantiomeric Etiocholanolone Interact with Distinct Sites on the Rat α1β2γ2L GABAA Receptor

  title={Natural and Enantiomeric Etiocholanolone Interact with Distinct Sites on the Rat $\alpha$1$\beta$2$\gamma$2L GABAA Receptor},
  author={Ping Li and John R Bracamontes and Bryson W. Katona and Douglas F. Covey and Joe Henry Steinbach and Gustav Akk},
  journal={Molecular Pharmacology},
  pages={1582 - 1590}
We have studied the ability of the androgen etiocholanolone and its enantiomer (ent-etiocholanolone) to modulate rat α1β2γ2L GABAA receptor function transiently expressed in human embryonic kidney cells. Studies on steroid enantiomer pairs can yield powerful new information on the pharmacology of steroid interactions with the GABAA receptor. Both steroids enhance currents elicited by GABA, but ent-etiocholanolone is much more powerful than etiocholanolone at producing potentiation. At a low… 

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