Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells.

@article{Yonezawa2003NaturalAI,
  title={Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells.},
  author={Akihito Yonezawa and Rimpei Morita and Akifumi Takaori-Kondo and Norimitsu Kadowaki and Toshio Kitawaki and Toshiyuki Hori and Takashi Uchiyama},
  journal={Journal of virology},
  year={2003},
  volume={77 6},
  pages={3777-84}
}
Natural alpha interferon (IFN-alpha)-producing cells (IPCs) are now recognized as identical to plasmacytoid dendritic cell (DC) precursors in human blood and are thought to play an important role in antiviral immunity. In the present study, we examined the susceptibility as well as the cellular responses of IPCs to human immunodeficiency virus type 1 (HIV-1) infection. HLA-DR(+) CD11c(-) lineage-negative cells (IPCs) were purified from peripheral blood mononuclear cells by magnetic-bead… CONTINUE READING