Natural Substances as New Potential Strategies for the Treatment of Leishmaniosisin Dogs

  title={Natural Substances as New Potential Strategies for the Treatment of Leishmaniosisin Dogs},
  author={De Vito Virginia and Helen C. Owen and Amnart Poapolathep and Giorgi Mario},
  journal={American Journal of Animal and Veterinary Sciences},
Leishmaniasis is a disease caused by the protozoan parasites Leishmania, infecting numerous mammal species. Canine leishmaniasis is potentially zoonotic and causes severe fatal disease in dogs. The discovery of new natural products extracted from medicinal plants or compounds derived from them, such as quercetin, hesperidin, vitamin c, horse chestnut extract and selenium could represent a valuable source of new medicinal agents for treating leishmaniasis in dogs. 
An Overview on Anticancer Drugs with Antileishmanial Activity
The present article mainly reviews the anticancer drugs that have been tested for their anti-leishmanial effects in both in vitro and in vivo and mainly reviews Miltefosin.
The Therapeutic Effects of Quercetin in a Canine Model of Low-dose Lipopolysaccharide-Induced Sepsis Compared with Hydrocortisone
It is suggested that quercetin protects RBCs in the early stages of sepsis and de- creases organs dysfunction (heart and liver), therefore it has a positive influence on sepsi and may be more effective than routine corticosteroid (hydrocortisone) therapy.


Plant derived therapeutics for the treatment of Leishmaniasis.
An overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells is provided.
Canine leishmaniosis--new concepts and insights on an expanding zoonosis: part two.
Infection with Leishmania infantum is considerably more prevalent than clinical disease, and infected dogs with no signs of disease might, potentially, transmit infection.
Leishmaniasis: drug resistance and natural products (review).
A brief overview of the current treatment and the active principles of established drugs is provided, and the mechanisms of drug resistance and natural products that are promising leads for the development of novel chemotherapeutics are focused on.
Recent advances in leishmaniosis in pet animals: epidemiology, diagnostics and anti-vectorial prophylaxis.
Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one.
An updated view on progress in elucidating the epidemiology and pathogenesis of canine leishmaniosis is presented, and the second part focuses on advances in diagnosis, treatment and prevention.
Canine leishmaniasis.
New findings have led to better understanding of the disease and have helped in the development of new diagnostic methods and control measures against the infection, such as insecticide-impregnated collars for dogs, new drugs and treatment protocols, and second generation vaccines.
Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis.
The efficacy of five naturally occurring flavonoids in arresting the development of anemia during the postinfection period is revealed and quercetin was most successful in inhibiting the oxidation of proteins and lipids on the red cell membranes of infected animals.
The current status of zoonotic leishmaniases and approaches to disease control.
A number of tools have been developed for the control of the canine reservoir of L. infantum, including several canine vaccine candidates, in particular an FML Leishmania enriched fraction showing good clinical protection, and a number of insecticide-based preparations for dog protection against sand fly bites.
Analysis of immune responses in dogs with canine visceral leishmaniasis before, and after, drug treatment.
It is shown that, after treatment, immune cellular responses to leishmanial antigens, involved in protection against Leishmania infection, were established.