Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation

@inproceedings{Teklenburg2010NaturalSO,
  title={Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation},
  author={Gijs Teklenburg and Madhuri S. Salker and Mariam Molokhia and Stuart Lavery and Geoffrey H. Trew and Tepchongchit Aojanepong and Helen J. Mardon and Amali U. Lokugamage and Raj K. Rai and Christian Landles and Bernard A. J. Roelen and Siobhan Quenby and Ewart W. Kuijk and Annemieke Kavelaars and Cobi J Heijnen and Lesley Regan and Jan Joris Brosens and Nickolas S Macklon},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a receptive endometrium. Reproductive success in humans is however limited, largely because of the high prevalence of chromosomally abnormal preimplantation embryos. Moreover, the transient period of endometrial receptivity in humans uniquely coincides with differentiation of endometrial stromal cells (ESCs) into highly specialized… CONTINUE READING
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