Natural Selection Shapes Genome-Wide Patterns of Copy-Number Polymorphism in Drosophila melanogaster

@article{Emerson2008NaturalSS,
  title={Natural Selection Shapes Genome-Wide Patterns of Copy-Number Polymorphism in Drosophila melanogaster},
  author={J J Emerson and Margarida Cardoso-Moreira and Justin O. Borevitz and Manyuan Long},
  journal={Science},
  year={2008},
  volume={320},
  pages={1629 - 1631}
}
The role that natural selection plays in governing the locations and early evolution of copy-number mutations remains largely unexplored. We used high-density full-genome tiling arrays to create a fine-scale genomic map of copy-number polymorphisms (CNPs) in Drosophila melanogaster. We inferred a total of 2658 independent CNPs, 56% of which overlap genes. These include CNPs that are likely to be under positive selection, most notably high-frequency duplications encompassing toxin-response genes… 
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