Natural Selection During Functional Divergence to LMP7 and Proteasome Subunit X (PSMB5) Following Gene Duplication

  title={Natural Selection During Functional Divergence to LMP7 and Proteasome Subunit X (PSMB5) Following Gene Duplication},
  author={D. H. Bos},
  journal={Journal of Molecular Evolution},
  • D. H. Bos
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Evolution
  • The LMP7 and PSMB5 genes were created through an ancient gene duplication event of their ancestral locus. These proteins contain an active site of proteolysis, and LMP7 replaces PSMB5 as a component of the 20S proteasome after stimulation of cells by interferon-γ. Replacement of PSMB5 by LMP7 changes the profile of the products of 20S proteasome processing, predisposing digested peptides for transport to and display by the immune system. The purpose of this study is to investigate evolutionary… CONTINUE READING
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