Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

@article{Gruenheid1997NaturalRT,
  title={Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the  Membrane of the Phagosome},
  author={Samantha Gruenheid and Elhanan Pinner and Michel Desjardins and Philippe Gros},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={717 - 730}
}
The Nramp1 (natural-resistance-associated macrophage protein 1) locus (Bcg, Ity, Lsh) controls the innate resistance or susceptibility of mice to infection with a group of unrelated intracellular parasites which includes Salmonella, Leishmania, and Mycobacterium. Nramp1 is expressed exclusively in professional phagocytes and encodes an integral membrane protein that shares structural characteristics with ion channels and transporters. Its function and mechanism of action remain unknown. The… CONTINUE READING

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