Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV Properties

@article{Detheux2000NaturalPP,
  title={Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV Properties},
  author={Michel Detheux and Ludger Staendker and Jalal Vakili and Jan M{\"u}nch and Ulf Forssmann and Knut Adermann and Stefan P{\"o}hlmann and G. Vassart and Frank Kirchhoff and Marc Parmentier and W Forssmann},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={1501 - 1508}
}
Hemofiltrate CC chemokine (HCC)-1 is a recently described human chemokine that is constitutively expressed in numerous tissues and is present at high concentrations in normal plasma. Using a cell line expressing CC chemokine receptor (CCR)5 as a bioassay, we isolated from human hemofiltrate an HCC-1 variant lacking the first eight amino acids. HCC-1[9-74] was a potent agonist of CCR1, CCR3, and CCR5 and promoted calcium flux and chemotaxis of T lymphoblasts, monocytes, and eosinophils. It also… CONTINUE READING

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