Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets.

@article{Safe2016NaturalPA,
  title={Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets.},
  author={Stephen Safe and Ravi Kasiappan},
  journal={Phytotherapy research : PTR},
  year={2016},
  volume={30 11},
  pages={
          1723-1732
        }
}
Naturally occurring anticancer agents and their derivatives act on multiple pathways to inhibit carcinogenesis and their inhibition of migration, invasion, growth, survival, and metastasis is associated with downregulation of genes associated with these responses. Several phytochemical-derived anticancer drugs including curcumin, betulinic acid, phenethylisothiocyanate and celastrol, and many others induce reactive oxygen species, and their effects on gene regulation show some overlap in… CONTINUE READING
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