Natural Killer Cells: Development, Maturation, and Clinical Utilization

@inproceedings{Abel2018NaturalKC,
  title={Natural Killer Cells: Development, Maturation, and Clinical Utilization},
  author={Alex M. Abel and Chao Yang and Monica S Thakar and Subramaniam Malarkannan},
  booktitle={Front. Immunol.},
  year={2018}
}
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells do not express polymorphic clonotypic receptors and utilize inhibitory receptors (killer immunoglobulin-like receptor and Ly49) to develop, mature, and recognize "self" from "non-self." The essential roles of common gamma cytokines such as interleukin (IL)-2, IL-7, and IL-15 in the commitment and development of… CONTINUE READING

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