Natural IgM in immune equilibrium and harnessing their therapeutic potential.

  title={Natural IgM in immune equilibrium and harnessing their therapeutic potential.},
  author={Srini V Kaveri and Gregg J Silverman and Jagadeesh Bayry},
  journal={Journal of immunology},
  volume={188 3},
Natural IgM Abs are the constitutively secreted products of B1 cells (CD5(+) in mice and CD20(+)CD27(+)CD43(+)CD70(-) in humans) that have important and diverse roles in health and disease. Whereas the role of natural IgM as the first line of defense for protection against invading microbes has been extensively investigated, more recent reports have highlighted their potential roles in the maintenance of tissue homeostasis via clearance of apoptotic and altered cells through complement… CONTINUE READING
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