Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

@inproceedings{Narang2017NaturalIA,
  title={Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement},
  author={Aarti Narang and Fei Qiao and C Scott Atkinson and H Lily Zhu and Xiaofeng Yang and Liudmila Kulik and V. Michael Holers and Stephen Tomlinson},
  booktitle={Journal of Neuroinflammation},
  year={2017}
}
Natural IgM antibodies (Abs) function as innate immune sensors of injury via recognition of neoepitopes expressed on damaged cells, although how this recognition systems function following spinal cord injury (SCI) exposes various neoepitopes and their precise nature remains largely unknown. Here, we investigated the role of two natural IgM monoclonal Abs (mAbs), B4 and C2, that recognize post-ischemic neoepitopes following ischemia and reperfusion in other tissues. Identification of post-SCI… CONTINUE READING
3 Extracted Citations
32 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…