Natural History of Opportunistic Disease in an HIV-Infected Urban Clinical Cohort

@article{Moore1996NaturalHO,
  title={Natural History of Opportunistic Disease in an HIV-Infected Urban Clinical Cohort},
  author={R. D. Moore and Richard E. Chaisson},
  journal={Annals of Internal Medicine},
  year={1996},
  volume={124},
  pages={633-642}
}
Since the beginning of the human immunodeficiency virus (HIV) epidemic, opportunistic infections and cancers have been recognized as common complications of HIV infection [1-3]. As immunosuppression from HIV infection progresses, the overall incidence of opportunistic disease increases [4, 5]; however, the risk for individual opportunistic illnesses varies with the specific degree of immunosuppression [6]. For example, infections with herpesviruses, Candida species, or pyogenic bacteria may… 
Human Immunodeficiency Virus-Related Opportunistic Infections in the Era of Highly Active Antiretroviral Therapy
TLDR
Empiriologic data concerning the frequency of opportunistic infections in the era of highly active antiretroviral therapy, as well as specific studies of clinical outcome for patients enrolled in clinical trials, clearly demonstrate that highly active anti-viral therapy (HAART) reduces susceptibility to opportunistic infection.
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TLDR
Most opportunistic diseases increase the risk of death independently of CD4 cell count, and data support the hypothesis that opportunistic Diseases enhance HIV pathogenesis and further underscore the importance of prophylaxis.
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TLDR
The pattern of OIs among the study group did not differ significantly from patients not receiving ART and the effect of ART on CD4 count differs from patient to patient based on the degree of depletion of CD4 number before the initiation of ART, drug adherence, concomitant OIs and their treatment.
Infections in HIV-Infected Patients
TLDR
This chapter will highlight the epidemiology, pathogenesis, clinical presentation, management, prognosis, and prevention of common infections that occur in HIV-infected patients.
Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy.
  • J. Kaplan, D. Hanson, J. Jones
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2000
TLDR
The incidence of nearly all AIDS-defining opportunistic infections (OIs) decreased significantly in the United States during 1992-1998; decreases in the most common OIs were more pronounced in 1996-1998, during which time highly active antiretroviral therapy (HAART) was introduced into medical care.
Clinical spectrum, morbidity, and mortality of acquired immunodeficiency syndrome in Taiwan: a 5-year prospective study.
TLDR
Morbidity and mortality were declining with each study year even in a population consisting mainly of patients at the advanced stage of HIV infection in Taiwan, and earlier diagnosis, accumulation of clinical experience, and use of HAART were associated with lower mortality rates.
Spectrum of opportunistic infections with correlation to CD4 counts in newly diagnosed HIV seropositive cases
TLDR
Evaluating the different type of infections and identifying the frequent pathogens affecting the HIV patients who are attending a tertiary care hospital in India helps the clinicians in proper guidance to come up with right diagnosis and early response to manage the patients in resource poor countries like India.
Natural history of human immunodeficiency virus disease in southern India.
TLDR
In a retrospective analysis of patients receiving care at YRG Center for AIDS Research and Education, a tertiary HIV referral center in southern India, the mean duration of survival from serodiagnosis was 92 months and patients who had > or =1 opportunistic infection were two times more likely to die.
Opportunistic Infections and Complications in Human Immunodeficiency Virus-1-Infected Children: Correlation with immune status.
TLDR
It is observed that the severity and frequency of opportunistic complications in paediatric patients with HIV-1 increased with a fall in the CD4 count, which may give treating physicians an initial idea about the immune status of each child and could also be used as a biological marker of HAART efficacy.
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