Natural HLA Class I Polymorphism Controls the Pathway of Antigen Presentation and Susceptibility to Viral Evasion

@article{Zernich2004NaturalHC,
  title={Natural HLA Class I Polymorphism Controls the Pathway of Antigen Presentation and Susceptibility to Viral Evasion},
  author={Danielle Zernich and Anthony W. Purcell and Whitney A. Macdonald and Lars Kjer-Nielsen and Lauren K. Ely and Nihay Laham and Tanya Crockford and Nicole A Mifsud and Mandvi Bharadwaj and Linus Chang and Brian D. Tait and Rhonda Holdsworth and Andrew G. Brooks and Stephen P. Bottomley and Travis Beddoe and Chen Au Peh and Jamie Rossjohn and James McCluskey},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={13 - 24}
}
HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into the transporter associated with Ag presentation (TAP)-associated peptide loading complex even under conditions of extreme peptide starvation… CONTINUE READING

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