Natural Exceptions to Normal Gonad Development in Mammals

@article{Jimnez2012NaturalET,
  title={Natural Exceptions to Normal Gonad Development in Mammals},
  author={R. Jim{\'e}nez and F. J. Barrionuevo and M. Burgos},
  journal={Sexual Development},
  year={2012},
  volume={7},
  pages={147 - 162}
}
Gonads are the only organs with 2 possible developmental pathways, testis or ovary. A consequence of this unique feature is that mutations in genes controlling gonad development give rise not only to gonadal malformation or dysfunction but also to frequent cases of sex reversal, including XY females, XX males and intersexes. Most of our current knowledge on mammalian sex determination, the genetic process by which the gonadal primordia are committed to differentiate as either testes or ovaries… Expand
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