Natural Cyclopeptides as Anticancer Agents in the Last 20 Years

@article{Zhang2021NaturalCA,
  title={Natural Cyclopeptides as Anticancer Agents in the Last 20 Years},
  author={Jia-Nan Zhang and Yi-Xuan Xia and Hong-Jie Zhang},
  journal={International Journal of Molecular Sciences},
  year={2021},
  volume={22}
}
Cyclopeptides or cyclic peptides are polypeptides formed by ring closing of terminal amino acids. A large number of natural cyclopeptides have been reported to be highly effective against different cancer cells, some of which are renowned for their clinical uses. Compared to linear peptides, cyclopeptides have absolute advantages of structural rigidity, biochemical stability, binding affinity as well as membrane permeability, which contribute greatly to their anticancer potency. Therefore, the… Expand

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