Natural CD4(+) T-cell responses against Trypanosoma cruzi KMP-11 protein in chronic chagasic patients.

@article{Cullar2009NaturalCT,
  title={Natural CD4(+) T-cell responses against Trypanosoma cruzi KMP-11 protein in chronic chagasic patients.},
  author={Adriana Cu{\'e}llar and Francia Rojas and Natalia I. Bola{\~n}os and Hugo D{\'i}ez and Mar{\'i}a Del Carmen Thomas and F. Acevedo Rosas and Victor H Velasco and Manuel Carlos L{\'o}pez and J M Gonz{\'a}lez and Concepci{\'o}n Puerta},
  journal={Immunology and cell biology},
  year={2009},
  volume={87 2},
  pages={
          149-53
        }
}
Trypanosoma cruzi kinetoplastid membrane protein-11 (KMP-11) is able to induce protective immunity in mice. In humans, T-cell immunity during Chagas disease has been documented using parasite antigens allowing the identification of specific CD8(+) T cells. However, little is known about the CD4(+) T-cell response during the evolution of the disease. In this paper, the induction of a natural CD4(+) T-cell response against the KMP-11 protein in T. cruzi infected humans was studied to assess… CONTINUE READING

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