Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

@article{Kiss2011NaturalAH,
  title={Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles},
  author={Elina A. Kiss and C{\'e}dric Vonarbourg and Stefan Kopfmann and Elias Hobeika and Daniela Finke and Charlotte Esser and Andreas Diefenbach},
  journal={Science},
  year={2011},
  volume={334},
  pages={1561 - 1565}
}
Nutrients can shape immune system development function through aryl hydrocarbon receptor signaling. Innate lymphoid cells (ILC) expressing the transcription factor RORγt induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. RORγt+ ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is… 
Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt+ Innate Lymphoid Cells and Intraepithelial Lymphocytes
TLDR
The role of AhR signaling for the maintenance of intestinal immune cells and its impact on the immunological protection against intestinal infections and debilitating chronic inflammatory disorders is reviewed.
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Intestinal Group 2 Innate Lymphoid Cell Function
TLDR
It is shown that aryl hydrocarbon receptor (Ahr) expression in the gut regulates ILC balance, and a central role for gut adaptation of Ahr expression in regulating the ILC2‐ILC3 balance is suggested.
Aryl hydrocarbon receptor
TLDR
AhR represents the first evidence of a molecular link between diet and immunity at intestinal mucosal surfaces and mediates the maintenance of Retinoic acid related orphan receptor γ t-expressing innate lymphoid cells (RORγt+ ILC) in the gut and consequently formation of postnatal lymphoid follicles.
Feedback Control of AHR Signaling Regulates Intestinal Immunity
TLDR
The data indicate that intestinal epithelial cells serve as gatekeepers for the supply of AHR ligands to the host and emphasize the importance of feedback control in modulating AHR pathway activation.
Regulation of Innate Lymphoid Cells by Aryl Hydrocarbon Receptor
TLDR
The molecular mechanisms of the action of Ahr expression and activity in regulation of ILCs in immunity and inflammation, and the interaction between Ahr and other pathways/transcription factors in ILC development and function with their implication in disease are discussed.
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor
TLDR
It is shown that the AhRR is predominantly expressed in immune cells of the skin and intestine, different from other AhR target genes, and contributes to the maintenance of colonic intraepithelial lymphocytes and prevents excessive IL-1β production and Th17/Tc17 differentiation.
Aryl hydrocarbon receptor promotes RORγt+ Group 3 ILCs and controls intestinal immunity and inflammation
TLDR
The development and function of RORγt+ group 3 ILCs are focused on, the role of Ahr in intestinal immunity and inflammation in mice and in humans is discussed, and new therapeutic means to target Ahr are discussed for future treatment of infectious and autoimmune diseases.
Aryl hydrocarbon receptor and intestinal immunity
TLDR
The current understanding of the functions of AhR in the mucosal immune system is reviewed with a focus on its role in intestinal barrier function and intestinal immune cells, as well as in intestinal homeostasis.
The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis
TLDR
Novel findings in the role of AhR in regulation of intestinal immune homeostasis and inflammation may help explain how environmental factors may regulate mucosal immune responses.
Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease
  • Minyi Qian, Jun Liu, +15 authors Lirui Wang
  • Medicine
    Cellular and molecular gastroenterology and hepatology
  • 2021
TLDR
The results indicate that targeted restoration of IEC intrinsic Ahr function may present as a novel approach for ALD treatment, and this work aims to evaluate the therapeutic potentials of intestinal Ahr activation forALD treatment.
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