Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

@article{Kiss2011NaturalAH,
  title={Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles},
  author={Elina A. Kiss and C. Vonarbourg and Stefanie Kopfmann and E. Hobeika and D. Finke and C. Esser and A. Diefenbach},
  journal={Science},
  year={2011},
  volume={334},
  pages={1561 - 1565}
}
  • Elina A. Kiss, C. Vonarbourg, +4 authors A. Diefenbach
  • Published 2011
  • Biology, Medicine
  • Science
  • Nutrients can shape immune system development function through aryl hydrocarbon receptor signaling. Innate lymphoid cells (ILC) expressing the transcription factor RORγt induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. RORγt+ ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is… CONTINUE READING
    571 Citations

    Paper Mentions

    Interventional Clinical Trial
    This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the activation of a specific cellular component: the aryl hydrocarbon receptor.  
    ConditionsDiet Modification
    InterventionDietary Supplement
    Diet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance
    • 11
    • Highly Influenced
    • PDF
    Human RORgtCD34 Cells Are Lineage-Specified Progenitors of Group 3 RORgt Innate Lymphoid Cells
    • 1
    • Highly Influenced
    • PDF
    Impact of cigarette smoke and IL-17A activation on asthmatic patients with chronic rhinosinusitis
    • 4
    • Highly Influenced
    • PDF
    Aryl hydrocarbon receptor signaling involves in the human intestinal ILC3/ILC1 conversion in the inflamed terminal ileum of Crohn’s disease patients
    • 14
    • Highly Influenced
    Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.
    • 14
    • Highly Influenced
    Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.
    • 101
    • Highly Influenced
    Aryl hydrocarbon receptor promotes RORγt+ Group 3 ILCs and controls intestinal immunity and inflammation
    • 45
    • Highly Influenced
    Food Components and the Immune System: From Tonic Agents to Allergens
    • 38
    • Highly Influenced
    • PDF
    The aryl hydrocarbon receptor: a sentinel safeguarding the survival of immune cells in the gut.
    • 4
    • Highly Influenced

    References

    SHOWING 1-10 OF 49 REFERENCES
    Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant γδ T Cells in the Murine Epidermis
    • 108
    • PDF
    Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells
    • 190
    • PDF
    Immune adaptations that maintain homeostasis with the intestinal microbiota
    • 996