Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

@article{Kiss2011NaturalAH,
  title={Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles},
  author={Elina A. Kiss and C. Vonarbourg and Stefanie Kopfmann and E. Hobeika and D. Finke and C. Esser and A. Diefenbach},
  journal={Science},
  year={2011},
  volume={334},
  pages={1561 - 1565}
}
  • Elina A. Kiss, C. Vonarbourg, +4 authors A. Diefenbach
  • Published 2011
  • Biology, Medicine
  • Science
    • Nutrients can shape immune system development function through aryl hydrocarbon receptor signaling. Innate lymphoid cells (ILC) expressing the transcription factor RORγt induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. RORγt+ ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is… CONTINUE READING
    View on AAAS
    ncbi.nlm.nih.gov
    575 Citations
    Highly Influential Citations
    47
    Background Citations
    204
    Methods Citations
    6
    Results Citations
    9

    Paper Mentions

    Interventional Clinical Trial
    The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation
    This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the activation of a specific cellular component: the aryl hydrocarbon receptor.  
    ConditionsDiet Modification
    InterventionDietary Supplement
    McMaster University
    November 2017 - June 2018
    Blog Post
    You AhR What You Eat: Linking Diet and Immunity.
    Nutri-Link Ltd - Clinical Education
    29 November 2011
    575 Citations
    Citation Type

    Citation Type

    Diet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance
    • 13
    • Highly Influenced
    • PDF
    Human RORgtCD34 Cells Are Lineage-Specified Progenitors of Group 3 RORgt Innate Lymphoid Cells
    • 1
    • Highly Influenced
    • PDF
    Impact of cigarette smoke and IL-17A activation on asthmatic patients with chronic rhinosinusitis
    • 4
    • Highly Influenced
    • PDF
    Aryl hydrocarbon receptor signaling involves in the human intestinal ILC3/ILC1 conversion in the inflamed terminal ileum of Crohn’s disease patients
    • 14
    • Highly Influenced
    Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway.
    • 14
    • Highly Influenced
    Special Section on Drug Metabolism and the Microbiome Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes s
    • 1
    • Highly Influenced
    • PDF
    Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.
    • 101
    • Highly Influenced
    Aryl hydrocarbon receptor promotes RORγt+ Group 3 ILCs and controls intestinal immunity and inflammation
    • 45
    • Highly Influenced
    Food Components and the Immune System: From Tonic Agents to Allergens
    • 38
    • Highly Influenced
    • PDF
    The aryl hydrocarbon receptor: a sentinel safeguarding the survival of immune cells in the gut.
    • 4
    • Highly Influenced

    References

    SHOWING 1-10 OF 49 REFERENCES
    Aryl Hydrocarbon Receptor Is Critical for Homeostasis of Invariant γδ T Cells in the Murine Epidermis
    • 108
    • PDF
    CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.
    • 500
    Control of epithelial cell function by interleukin‐22‐producing RORγt+ innate lymphoid cells
    • 98
    Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
    • 557
    • PDF
    Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • 1,177
    • PDF
    Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells
    • 192
    • PDF
    Predicting a Human Gut Microbiota’s Response to Diet in Gnotobiotic Mice
    • 423
    RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
    • 218
    • PDF
    Immune adaptations that maintain homeostasis with the intestinal microbiota
    • 1,004
    Kit Ligand and Il7 Differentially Regulate Peyer’s Patch and Lymph Node Development
    • 48
    • PDF