Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles
@article{Kiss2011NaturalAH, title={Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles}, author={Elina A. Kiss and C. Vonarbourg and Stefanie Kopfmann and E. Hobeika and D. Finke and C. Esser and A. Diefenbach}, journal={Science}, year={2011}, volume={334}, pages={1561 - 1565} }
Nutrients can shape immune system development function through aryl hydrocarbon receptor signaling. Innate lymphoid cells (ILC) expressing the transcription factor RORγt induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. RORγt+ ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is… CONTINUE READING
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Interventional Clinical Trial
This study evaluates the role of dietary L-tryptophan, an essential amino acid, in the
activation of a specific cellular component: the aryl hydrocarbon receptor.
Conditions | Diet Modification |
---|---|
Intervention | Dietary Supplement |
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