Natural Abenquines and Their Synthetic Analogues Exert Algicidal Activity against Bloom-Forming Cyanobacteria.

@article{NainPerez2017NaturalAA,
  title={Natural Abenquines and Their Synthetic Analogues Exert Algicidal Activity against Bloom-Forming Cyanobacteria.},
  author={Amalyn Nain-Perez and Luiz Cl{\'a}udio Almeida Barbosa and C{\'e}lia Regina {\'A}lvares Maltha and Giuseppe Forlani},
  journal={Journal of natural products},
  year={2017},
  volume={80 4},
  pages={
          813-818
        }
}
  • Amalyn Nain-Perez, Luiz Cláudio Almeida Barbosa, +1 author Giuseppe Forlani
  • Published in Journal of natural products 2017
  • Biology, Medicine
  • Abenquines are natural quinones, produced by some Streptomycetes, showing the ability to inhibit cyanobacterial growth in the 1 to 100 μM range. To further elucidate their biological significance, the synthesis of several analogues (4f-h, 5a-h) allowed us to identify some steric and electronic requirements for bioactivity. Replacing the acetyl by a benzoyl group in the quinone core and also changing the amino acid moiety with ethylpyrimidinyl or ethylpyrrolidinyl groups resulted in analogues 25… CONTINUE READING

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