Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth

@article{NietoSampedro2004NaturalSA,
  title={Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth},
  author={Manuel Nieto‐Sampedro and Ernesto Doncel-P{\'e}rez and Alfonso Fern{\'a}ndez-Mayoralas},
  journal={Expert Opinion on Therapeutic Patents},
  year={2004},
  volume={14},
  pages={487 - 497}
}
Neurostatin, a natural glycosphingolipid inhibitor of astroblast and astrocytoma division, present in mammalian brain, is the modified ganglioside O-acetylated GD1b. It is cytostatic for rat astroblasts, C6 glioma cells and various human astrocytoma lines grades III and IV, with median inhibitory dose values ranging 1 – 5 μM. Neurostatin was shown not to affect primary or transformed fibroblast division at concentrations of ≥ 10 μM. A synthetic neurostatin analogue, NF-115, consisting of an… 
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References

SHOWING 1-10 OF 74 REFERENCES

Purification and Structure of Neurostatin, an Inhibitor of Astrocyte Division of Mammalian Brain

Mono‐ and bidimensional NMR spectra, together with biochemical studies, suggest that neurostatin may be the 9‐O‐monoacetyl ester of GD1b, which is cytostatic for astroblasts, C6 glioma cells, and various human astrocytomas grades III and IV.

Experimental Brain Glioma: Growth Arrest and Destruction By a Blood-Group-Related Tetrasaccharide

A synthetic tetrasaccharide (TS4), structurally related to blood groups, inhibited the proliferation of C6 glioma cells in culture and the growth of tumors formed after intracerebral transplantation of C 6 cells, and offered the possibility of selective tumor treatment.

Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase.

Treatment of the host with a novel p.o.O. inhibitor of glucosylceramide synthesis, the imino sugar OGT2378, inhibits MEB4 melanoma tumor growth in a syngeneic, orthotopic murine model suggests that inhibition of glycosphingolipid synthesis is a promising and now feasible novel therapeutic approach to inhibit tumor progression.

N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset.

Novel disaccharide inhibitors of human glioma cell division.

The antimitotic activities of the compounds tested were essentially independent of the mitogen used to stimulate cell division.

Control of glial number: Purification from mammalian brain extracts of an inhibitor of astrocyte division

The biological and immunological properties of this brain inhibitor were identical to those of the EGF receptor‐related inhibitor previously described with the acronym ERI, and the glial inhibitor has been renamed neurostatin.

Tumor gangliosides inhibit the tumor-specific immune response.

The clear conclusion that tumor-derived gangliosides inhibit syngeneic antitumor immune responses implicates these molecules as a potent factor in promoting tumor formation and progression.

Central neural tumor destruction by controlled release of a synthetic glycoside dispersed in a biodegradable polymeric matrix.

An octyl N-acetylglucosaminide derivative with a pentaerythritol chain at position 6 has been synthesized and evaluated as an inhibitor of neural tumor growth and caused the destruction of cultured human astroblastoma obtained after surgical biopsy.

Role of tumor-associated gangliosides in cancer progression.

Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides

A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was
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