Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth

  title={Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth},
  author={Manuel Nieto‐Sampedro and Ernesto Doncel-P{\'e}rez and Alfonso Fern{\'a}ndez-Mayoralas},
  journal={Expert Opinion on Therapeutic Patents},
  pages={487 - 497}
Neurostatin, a natural glycosphingolipid inhibitor of astroblast and astrocytoma division, present in mammalian brain, is the modified ganglioside O-acetylated GD1b. It is cytostatic for rat astroblasts, C6 glioma cells and various human astrocytoma lines grades III and IV, with median inhibitory dose values ranging 1 – 5 μM. Neurostatin was shown not to affect primary or transformed fibroblast division at concentrations of ≥ 10 μM. A synthetic neurostatin analogue, NF-115, consisting of an… 
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