Natriuretic peptide receptors mediate different responses in rat renal microvessels.

  title={Natriuretic peptide receptors mediate different responses in rat renal microvessels.},
  author={Karlhans Endlich and M. Steinhausen},
  journal={Kidney international},
  volume={52 1},
Atrial natriuretic peptide (ANP) has unique effects on the renal vasculature, in that it dilates preglomerular vessels and constricts efferent arterioles. In the present study we aimed to characterize the natriuretic peptide receptor (NPR) subtypes, which mediate the renovascular effects of ANP, using in vivo microscopy in the split hydronephrotic kidney model of rats. ANP (10(-9) and 3.10(-9)), which binds to NPR-A and NPR-C, dilated preglomerular vessels and constricted efferent arterioles… CONTINUE READING


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