Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.

@article{Doyle2002NatriureticPR,
  title={Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.},
  author={Donald D Doyle and Judy Upshaw-Earley and Eric L. Bell and H. Clive Palfrey},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 6},
  pages={H2117-23}
}
We assessed the cellular localization and relative concentration of the C-type natriuretic peptide (CNP) guanylate cyclase-B (GC-B) receptor in the adult rat heart ventricle by several techniques. In frozen sections of the ventricle, anti-receptor antibody stained the vasculature and cells interstitial to myocytes, but not the myocytes themselves. The same antibody detected GC-B in immunoblots of protein extracts of nonmyocytes, but not myocytes and recognized an equivalent protein in extracts… CONTINUE READING

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