Natriuretic effect of caffeine: assessment of segmental sodium reabsorption in humans.

@article{Shirley2002NatriureticEO,
  title={Natriuretic effect of caffeine: assessment of segmental sodium reabsorption in humans.},
  author={D. G. Shirley and S. J. Walter and F. H. Noormohamed},
  journal={Clinical science},
  year={2002},
  volume={103 5},
  pages={
          461-6
        }
}
In order to assess the intrarenal mechanisms responsible for the natriuretic action of caffeine, the renal clearances of (51)Cr-EDTA [used as a measure of glomerular filtration rate (GFR)] and lithium (used as an index of end-proximal fluid delivery) were measured in eight healthy males before (control period) and immediately after (experimental period) a 400 mg oral dose of caffeine (given over 90 min) or placebo. In caffeine-treated subjects, the fractional excretion of sodium rose from 1.00… 

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