Natriuretic and water diuretic effects of central alpha 2-adrenoceptor agonists.


Methyldopa, clonidine, and a more recently developed drug, guanabenz, have similar antihypertensive mechanisms, predominantly suppression of central sympathetic outflow by alpha 2-receptor agonism and consequent reduction in peripheral sympathetic activity. Recent studies clearly demonstrate an important role of the sympathetic nervous system in the control… (More)


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