Natriuretic and renoprotective effect of chronic oral neutral endopeptidase inhibition in acute renal failure.


Neutral endopeptidase (NEP: EC is involved in the degradation of peptides such as atrial natriuretic peptide, angiotensin II (AngII), and endothelin-1 (ET-1). In this study we propose that NEP inhibition provides protection in glycerol-induced acute renal failure (ARF). Renal vascular responses were evaluated in ARF rats where ARF was induced by… (More)
DOI: 10.3109/08860221003611745


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