Natriuretic and antikaliuretic effects of uroguanylin and prouroguanylin in the rat.

@article{Moss2010NatriureticAA,
  title={Natriuretic and antikaliuretic effects of uroguanylin and prouroguanylin in the rat.},
  author={Nicholas G. Moss and Dorothy A Riguera and Robert C. Fellner and Christopher Cazzolla and Michael F. Goy},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 6},
  pages={F1433-42}
}
The peptide uroguanylin (Ugn) is stored and released as a propeptide (proUgn) by enterochromaffin cells in the intestine, and converted to Ugn and other metabolites in the renal tubules. Both proUgn and Ugn are natriuretic, although the response to proUgn is thought to depend on its conversion to Ugn within nephrons. To assess the efficiency of intrarenal conversion of proUgn to Ugn, we measured urinary Ugn excretion in rats following intravenous infusions of proUgn or Ugn. Infusion of 2 and 10… CONTINUE READING