Natriuresis in conscious dogs caused by increased carotid [Na+] during angiotensin II and aldosterone blockade.

@article{Emmeluth1994NatriuresisIC,
  title={Natriuresis in conscious dogs caused by increased carotid [Na+] during angiotensin II and aldosterone blockade.},
  author={Claus Emmeluth and Christian Drummer and Rupert Gerzer and Peter A. Flach Tijl De Bie},
  journal={Acta physiologica Scandinavica},
  year={1994},
  volume={151 3},
  pages={403-11}
}
The renal response to a selective increase in the Na+ concentration of the blood perfusing the central nervous system was investigated in conscious dogs treated with the converting enzyme inhibitor enalaprilat and the aldosterone antagonist canrenoate. In split-infusion experiments the plasma [Na+] of carotid blood was increased (approx. 6 mM) by bilateral infusion of hypertonic NaC1. Concomitantly distilled water was infused into the v. cava making the sum of the infusions isotonic. In control… CONTINUE READING
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