Natively unfolded proteins.

  title={Natively unfolded proteins.},
  author={Anthony L. Fink},
  journal={Current opinion in structural biology},
  volume={15 1},
It is now clear that a significant fraction of eukaryotic genomes encode proteins with substantial regions of disordered structure. In spite of the lack of structure, these proteins nevertheless are functional; many are involved in critical steps of the cell cycle and regulatory processes. In general, intrinsically disordered proteins interact with a target ligand (often DNA) and undergo a structural transition to a folded form when bound. Several features of intrinsically disordered proteins… CONTINUE READING
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